Atherosulinosis ndizomwe zimayambitsa matenda a mtima, omwe amakhalabe mtsogoleri wapadziko lonse lapansi wakufa.Insulin-like growth factor I (IGF1) yasonyezedwa kuti imachepetsa zochitika za mtima.Kulamulira kwa IGF1 kumachepetsa atherosclerosis ndi kuchepetsa macrophages a plaque mu ApoE-deficient (Apoe- /-) mbewa zimadyetsa zakudya zamafuta ambiri.Zotsatira zathu zam'mbuyomu zam'mimba zikuwonetsa kuti ma macrophages amagwira ntchito yayikulu pakuyanjanitsa zotsatira za IGF1 m'mitsempha ya atherosclerotic, koma njira yeniyeniyo sinadziwikebe. kupewa atherosulinosis.
Titatha kuswana mbewa za macrophage-enieni a IGF1-overexpressing transgenic mbewa ku Apoe-/- maziko (MF-IGF1 mbewa), tidayesa zolemetsa za atherosclerotic plaque, kukhazikika, komanso kulembera anthu amtundu wa monocyte. Zakudya zamafuta m'miyezi itatu.Tidawunikanso kuchuluka kwa cholesterol ndi mapangidwe a cell foam mu vivo ndi mu vitro.
Macrophage IGF1 overexpression inachepetsa zolemetsa zolemetsa ndi 30%, kuchepetsa macrophages a plaque ndi 47%, ndikulimbikitsa zinthu zomwe zimakhazikitsa phenotype. chemokine ligand 12 (CXCL12) .CXCL12 mapuloteni anachepetsedwa mu zolembera ndi peritoneal macrophages mu MF-IGF1 mbewa.In vitro, IGF1 inatsekereza kwathunthu oxidized low-density lipoprotein (oxLDL) -kuwonjezeka kwa kudalira kwa PCL12 mRNA kulembedwanso kwa CX12 mRNA% <0.01), ndi chithandizo cha IGF1 chinachepetsa mapuloteni a CXCL12 (56% kuchepetsa, P <0.001).
CXCL12 imachepetsa mafotokozedwe a ATP-binding cassette transporter A1 (ABCA1), chonyamulira chachikulu cha kolesterolini chomwe chimagwirizanitsa cholesterol efflux kuchokera ku macrophages. mu cholesterol efflux poika ma peritoneal macrophages ndi oxLDL ndipo tinapeza kuwonjezeka kwa 42% mu mbewa za MF-IGF1. Tinapezanso kuwonjezeka kwa 27% kwa cholesterol efflux m'maselo a THP-1 omwe amathandizidwa ndi IGF1 (100 ng / mL) ndi apolipoprotein AI. monga cholesterol receptor.
Zotsatira zathu zimasonyeza kuti macrophage IGF1 imachepetsa matenda a atherosclerosis ndipo imachepetsa CXCL12, chemokine yomwe yangoyamba kumene ku matenda a atherosclerosis.IGF1 ingachepetse CXCL12 mwa kuchepetsa kulembedwa kwa monocyte ndi kuwonjezeka kwa ABCA1, potero kumagwiritsa ntchito mphamvu yake ya atheroprotective, motero kuonjezera mphamvu ya cholesterol.
Kusintha kwa jini ya TTR (rs76992529; Val122Ile) kumawoneka mwa anthu okhawo aku Africa (kuchuluka kwa anthu: 3-4%) zomwe zimapangitsa kuti tetrameric transthyretin complex, yomwe imapezeka mu cholowa cha transthyretin amyloidosis.Kuwonongeka kwamtundu (hATTR) kumachulukana monga ma extracellular amyloid fibrils. Kuyerekeza zotsatira za kusiyana kwa TTR ya amyloidogenic pa chiopsezo cha mtima (HF) ndi kufa kwa zifukwa zonse m'gulu lalikulu, losiyana kwambiri la African Americans kungapereke chidziwitso cha chipatala cha kusiyana kumeneku. .Tinayesa anthu akuda mu kafukufuku wa Geographic and Racially Different Causes of Stroke (REGARDS) kuti tifufuze kugwirizana kwa kusintha kwa TTR Val122Ile ndi HF ndi kufa kwa zifukwa zonse.
Tinayesa anthu akuda aku America omwe adadziwonetsa okha mu kafukufuku wa REGARDS popanda HF poyambira.Poisson regression idagwiritsidwa ntchito poyesa kulephera kwa mtima komanso kufa chifukwa chazonse.Tinagwiritsa ntchito njira yosinthira Cox regression accounting accounting for demographic, chipatala komanso chikhalidwe cha anthu. zinthu, ndi chibadwa cha makolo a ku Africa kuti awone kuopsa kwa HF ndi kufa kwa zifukwa zonse mwa anthu omwe ali ndi kusiyana kwa chibadwa kwa TTR Val122Ile poyerekeza ndi omwe alibe zosiyana.
Pakati pa anthu akuda a 7,514 (zaka zapakati: zaka 64; 61% akazi), chiwerengero cha anthu amtundu wa TTR Val122Ile chinali 3.1% (232 onyamula; 7,282 osanyamula) . (95% CI: 11.5-21.9) pakati pa zonyamulira zosiyanasiyana ndi 7.2 (95% CI: 6.6-7.9) pakati pa zonyamula zopanda pake.Val122Ile zonyamulira zosiyanasiyana zinali ndi chiopsezo chachikulu chokhala ndi HF poyerekeza ndi osanyamula (HR: 2.46 [95% CI) : 1.72-3.53]; P <0.0001) .Chiwopsezo cha imfa zonse (pa zaka 1000 za munthu) zinali 41.5 (95% CI: 34.6-49.7) pakati pa zonyamulira zosiyanasiyana ndi 33.9 (95% CI: 32.5)-3 pakati pa zonyamula zosanyamula.Val122Ile zonyamulira zosiyanasiyana zinali ndi chiwopsezo chachikulu cha kufa kwa zifukwa zonse poyerekeza ndi osanyamula (HR: 1.44 [95% CI: 1.18-1.76]; P=0.0004) . kugwirizana ndi HF ndi zotsatira za imfa zonse.
Pagulu lalikulu la anthu akuda aku America, tikuwonetsa kuti kusintha kwa amyloid Val122Ile mu jini ya TTR kumalumikizidwa ndi chiwopsezo cha HF chambiri cha 2.5 komanso chiwopsezo chachikulu cha 40% cha kufa kwa zifukwa zonse. Thandizo, kupezeka kwa kusintha kwa TTR Val122Ile komwe kumapezeka kawirikawiri mwa anthu aku Africa kumatha kuonedwa kuti n'kotheka ndipo kumathandizira kupeza chithandizo msanga.
Kutsegula kwa guanylate cyclase/natriuretic peptide receptor A (GC-A/NPRA) pogwiritsa ntchito mahomoni amtima atrial ndi brain natriuretic peptides (ANP ndi BNP) kumatulutsa messenger wachiwiri cGMP.cGMP imayendetsa kutsika kwa sigino ndi zotsatira zachilengedwe za ANP/NPRA za okodzetsa. , diuretic, vasodilatory, antimitotic responses and cardiac antihypertrophic effects.Mawu a jini ya Npr1 (encoding GC-A/NPRA) amayendetsedwa ndi zokopa zingapo zakunja ndi zamkati, koma njira za mahomoni ndi epigenetic zomwe zimagwirizanitsa ndondomeko ya Npr1 sizikudziwika. Kafukufukuyu anali kuyesa ntchito ya vitamini D (vitD) pakuwongolera kulembedwa kwa jini ya Npr1 ndi kufotokozera mwa kuwongolera zinthu za epigenetic.
Kafukufuku wathu wa bioinformatic wa murine Npr1 wolimbikitsa adawulula kukhalapo kwa zinthu zinayi zoyankhira za vitD (VDREs) m'dera la -583 mpaka -495 la malo oyambira kulembera, ndi ndondomeko yabwino ya VDRE-monga mgwirizano. , zomangazo zinasinthidwa pang'onopang'ono m'maselo amtundu wa thoracic aortic smooth muscle (RTASMCs) ndi ma cell a mouse mesangial (MMCs) ndikuyesa zida ziwiri zoyesera za luciferase.Ntchito yolemba.
Kuyesa kwa Luciferase kunasonyeza kuti chithandizo cha vitamini D3 (1α,25-dihydroxy; VD3) chinawonjezera ntchito ya Npr1 yolimbikitsa kuposa 6-fold in the dose-dependent. kukhazikika, 3.5-fold mu RTASMCs ndi 4.7-fold mu RTASMCs, ndipo zotsatira zazikuluzikulu zinawonedwa pa 100 nM.VD3 zimawonjezera kuchuluka kwa mapuloteni a vitD receptor (VDR) m'njira yodalira mlingo.Pamaso pa VD3, histone Ntchito ya deacetylase (HDAC) inali 50% yoletsedwa monga momwe imayesedwera ndi ntchito ya HDAC / kuletsa ELISA kit. Kuwonjezera apo, chithandizo cha VD3 chochepetsera ma enzymes a HDAC amtundu wa HDAC, HDAC1 ndi HDAC3 mapuloteni, ndi ma histones omwe amadalira mlingo, H3 pa zotsalira za lysine 9 ndi 14 (H3-K9/14 ac) ndi lysine H4 pa asidi zotsalira 12 (H4-K14ac).
Zotsatira zimasonyeza kuti VD3 epigenetically imayang'anira jini la Npr1 poyang'anira kusintha kwa histone.Kuzindikiritsa zolinga za epigenetic za chizindikiro cha vitamini D monga olamulira a Npr1 gene transcript and protein expression adzakhala ndi zofunikira kwambiri pa matenda oopsa komanso kuwongolera mtima.
adawonetsa kuti kuphatikizika ndi superconductivity kumapangitsa kuti pakhale ma intracellular conduction mumagulu ang'onoang'ono a cardiomyocyte, kupititsa patsogolo kulumikizana ndi kumanzere kwa ventricular.
Kuyesera kunkachitika pogwiritsa ntchito luntha lochita kupanga mkati mwa maselo pogwiritsa ntchito malingaliro a quantum a entanglement ndi superconductivity;Mayendedwe amagetsi a intracellular kudutsa malire apakati (GI) opangidwa ndi enalapril (E.) ndi angiotensin II (Ang II) adayesedwa.E.Jekeseni pa 1 ug / ml (25 ug / ml) pa maminiti a 4. Malo otsetsereka amafikira pa valve pa 106% kutuluka mu thumba. kunalibe phiri.
Tikuganiza kuti malo otsetsereka amafikira pambuyo pochepetsa kutsekeka, koma osati ndi Ang II. Mu superconducting state, E. coli inali yothandiza kwambiri popititsa patsogolo kugwirizanitsa kwa myocyte yolephera, kupititsa patsogolo ntchito ya ventricle yakumanzere.
Matenda a Coronavirus (COVID-19) amayambira ku matenda asymptomatic mpaka kudwala kwambiri ndi kulephera kwa ziwalo zingapo. Cholesterol (TC), ndi kuopsa kwa matenda a COVID-19.
Tidawunikiranso mwadongosolo ndikuwunika kwa 1) kusiyana kwa HDL, LDL, TC, ndi triglyceride (TG) pakati pa odwala COVID-19 ndi owongolera athanzi 2) omwe ali ndi matenda oopsa komanso osadwala ndi COVID-19 Patient 3) COVID- Taphatikizanso zolemba za PubMed ndi Embase kuyambira pa Seputembara 1, 2021. Tidasanthula kusiyana kwapakati (pMD) pamilingo ya lipid (mg/dL) mwa magulu omwe ali pamwambapa pogwiritsa ntchito kusanthula kwachilengedwe. ndikuyesa kukondera kofalitsa pogwiritsa ntchito chiwembu cha funnel.
Mwa zolemba 441 zomwe zapezedwa, zolemba 29 (26 retrospective cohorts ndi 3 oyembekezeredwa cohorts) zidakwaniritsa njira zophatikizira, ndi otenga nawo gawo 256,721. Odwala omwe ali ndi COVID-19 anali ndi milingo yotsika ya HDL (pMD = -6.95) ndi TC (pMD = -14.9) (Table 1 ndi Chithunzi 1) LDL ndi TG milingo sanali kusiyana pakati pa odwala omwe ali ndi COVID-19. Odwala kwambiri COVID-19 anali ndi milingo yotsika ya HDL (pMD = -4.4), LDL (pMD = -4.4 ) ndi TC (pMD = -10.4) poyerekezera ndi odwala omwe sanali ovuta kwambiri a COVID-19. Odwala omwe anamwalira anali ndi milingo yotsika ya HDL (pMD = -2.5), LDL (pMD = -10.6) ndi TC (pMD = -14.9). Magulu a TG sanali osiyana ndi kuopsa kwa COVID-19 kapena kufa.
Odwala a COVID-19, otsika a HDL, LDL, ndi TC amalumikizidwa ndi kuuma komanso kufa. Kutupa komanso kusagwira ntchito kwa chiwindi. Miyezo ya lipid yamagazi imatha kuwonedwa ngati zinthu zomwe zingayambitse odwala COVID-19.
Atrial and brain natriuretic peptides (ANP ndi BNP) ndi mahomoni ozungulira a mtima omwe amatenga gawo lalikulu pakuwongolera kuthamanga kwa magazi ndi homeostasis yamadzimadzi ndikuwongolera kukonzanso kwa mtima kudzera mu vasodilatory ndi diuretic effects. Onse ANP ndi BNP amachita pomanga transmembrane guanylate cyclase/natriuretic peptide receptor-A (GC-A/NPR-A) .Kusokonezeka kwadongosolo kwa jini ya Npr1 (encoding GC-A/NPRA) kumabweretsa kuchuluka kwa voliyumu, kuthamanga kwa magazi, komanso kulephera kwamtima. .Cholinga cha kafukufukuyu chinali kufufuza ngati Npr1 imagwira ntchito yofunika kwambiri pakuwongolera glucose homeostasis mu Npr1 mbewa zosokoneza majini.
Amuna ndi akazi akuluakulu (masabata 16-18) Npr1 knockout haplotype (Npr1+/-, 1-copy), mtundu wakutchire (Npr1+/+, 2-copy) ndi gene duplication (Npr1+ +/++, 4 -copy) Mbewa anasala kudya kwa maola a 16 ndipo anali ndi mwayi wopeza madzi kwaulere. Kuwongolera kwapakamwa ndi intraperitoneal kwa shuga (2 g / kg kulemera kwa thupi) kunkachitidwa mu mbewa kuti adziwe kuyesa kwa glucose oral glucose tolerance test (OGTT) ndi intraperitoneal glucose tolerance test (IPGTT) . Miyezo idatsimikiziridwa ndi magazi a mchira pa 0, 15, 30, 60, 90, ndi 120 mphindi pogwiritsa ntchito AlphaTRAK Blood Glucose Monitoring System (Zoetis Inc, Kalamazoo, MI) . njira yotsekera mchira (Visitech 2000).
Zotsatira zinawonetsa kuti kuchuluka kwa shuga m'magazi mu mbewa zamtundu wa 2 (OGTT: 101 ± 4 mg / dL) kudakwera mpaka mphindi 15 pambuyo pa kuwongolera shuga (2 g/kg kulemera kwa thupi) ndikutsika mpaka pafupifupi mphindi 120 mwa amuna. .ndi akazi 98 ± 3 mg/dL, IPGT: amuna 100 ± 3 mg/dL, akazi 97 ± 4 mg/dL), pamene mbewa 1-kope, milingo ya shuga m'magazi anakhalabe okwera ngakhale mphindi 120 (OGTT: amuna 244 ± 6 mg / dL, wamkazi 220 ± 4 mg / dL, IPGT: mwamuna 250 ± 5 mg / dL, akazi 225 ± 6 mg / dL) poyerekeza ndi mbewa za 2-kopi. Mphindi 120 (OGTT: 78 ± 3 mg / dL kwa amuna, 73 ± 2 mg / dL kwa akazi, IPGT: 76 ± 4 mg / dL kwa amuna ndi 70 ± 3 mg / dL kwa akazi).dL) poyerekeza ndi mbewa za 2-copy. 2 mmHg mwa akazi). Momwemonso, mbewa za 4-kopi zinalinso ndi SBP yotsika kwambiri kuposa mbewa za 2 (85 ± 3 mmHg mwa amuna ndi 78 ± 2 mmHg mwa akazi) . ndi IPGTT.
Zomwe zapeza pano zikuwonetsa kuti Npr1 idalepheretsa kwambiri kukwera kwamphamvu kwa shuga m'magazi kutsatira zovuta za shuga komanso kukulitsa kusalolera kwa shuga mu mbewa zakuthengo komanso zofananira ndi majini, kutanthauza kuti Npr1 imatenga gawo lalikulu pakuwongolera kuchuluka kwa shuga komanso kutayika kwa Npr1 Action kumakhudza kwambiri. ntchito ya impso ndi mtima mu mbewa zosasinthika.Ntchitoyi idathandizidwa ndi thandizo la NIH (HL062147).
Central Arkansas Veterans Healthcare System John L. McClellan Memorial Veterans Hospital, Little Rock, Arkansas
Odwala omwe ali ndi matenda a impso (CKD) ndi omwe si a ST-segment elevation myocardial infarction (NSTEMI) amaimira vuto lalikulu lachipatala.Mgwirizano pakati pa maphunziro osadziwika ndi owonetsetsa ndi osadziwika. (2) Kodi zotsatira zake zimakhudzidwa ndi kuchuluka kwa aimpso? (3) Kodi chiwopsezo cha kufa ndi chofanana ndi chithandizo chamankhwala chokha m'maphunziro osasintha komanso owonera?
Maphunziro anasankhidwa malinga ndi mfundo zotsatirazi: (1) malipoti mwachisawawa kapena observational malipoti odwala NSTEMI ndi CKD (2) chiwerengero cha odwala ndi imfa kupezeka kwa invasive ndi ndiwofatsa chithandizo pa mlingo uliwonse wa aimpso ntchito, kuphatikizapo pafupifupi glomerular kusefera mlingo (eGFR). ) 30-60 ndi <30.Kusanthula kwa meta ndi mafananidwe amagulu ang'onoang'ono kunamalizidwa powerengera kuchuluka kwa zovuta za imfa kuchokera kumankhwala osokoneza bongo motsutsana ndi osamala.
(1) Maphunziro asanu osankhidwa mwachisawawa ndi maphunziro anayi owunikira adakwaniritsa njira zosankhidwa, ndipo odwala 362,486 omwe adalandira chithandizo chosokoneza kapena chodziletsa pakati pa 1994 ndi 2020.
(2) M'maphunziro osasinthika, chiŵerengero cha imfa chifukwa cha chithandizo chamankhwala kwa odwala omwe ali ndi eGFR 30-60 chinali 0.739, nthawi yodalirika (CI) inali 0.382-1.431, p = 0.370. chiŵerengero chazovuta za chithandizo chamankhwala cha imfa chinali 0.144, CI 0.012-0.892, p=0.037.
(3) M'maphunziro osadziwika bwino, chiwerengero cha imfa chifukwa cha chithandizo chamankhwala kwa odwala omwe ali ndi eGFR <30 chinali 0.790, CI 0.135-4.63, p = 0.794, p = 0.794. imfa, CI 0.281-0.552, p<.05.
(4) Chiwopsezo cha imfa kwa odwala omwe ali ndi eGFR 30-60 omwe amathandizidwa ndi chithandizo chokhazikika chokha chinali 0.128 (CI -0.001-0.227) mu gulu lachidziwitso chachisawawa ndi 0.44 (CI 0.227-0.6525) mu gulu lofufuza, p< 0.01 .Mu phunziro losasinthika Chiwopsezo cha imfa chapakati chinali 0.345 (CI -0.103-0.794) mwa odwala omwe ali ndi eGFR <30 kulandira chithandizo chokhazikika chokha ndi 0.463 (CI 0.00-0.926) mu maphunziro owonetsetsa, p = 0.579.
(1) Ngakhale zotsatira zabwino za chithandizo chamankhwala m'maphunziro osasinthika komanso olowa nawo, chiŵerengero cha imfa mu maphunziro owonetsetsa chinali chofunika kwambiri.
(2) Maphunziro owonetsetsa awonetsa kuti chithandizo chamankhwala chimakhala chochepa kwambiri cha imfa kwa odwala omwe ali ndi eGFR 30-60 ndi eGFR <30.
(3) Odwala omwe ali m'gulu loyang'anitsitsa anali ndi chiopsezo chachikulu cha imfa ndi chithandizo chokhazikika chokha.
(4) Kafukufuku wochulukirapo akufunika kuti apange chitsanzo chosankha odwala omwe angapindule kwambiri ndi mankhwala osokoneza bongo kapena osamalidwa.
(5) Zochepa za phunziroli zimaphatikizapo kusiyana kwa chiwerengero cha odwala m'magulu ophunzirira, kusowa kwa hemodynamic ndi angiographic deta malinga ndi eGFR, komanso kuthekera kuti maphunziro ena akuphatikizapo odwala omwe ali ndi angina pectoris osakhazikika kusiyana ndi NSTEMI.
Ngakhale kuti sayansi yapita patsogolo mu cardiology, cardiogenic shock monga vuto la acute myocardial infarction idakali vuto lachipatala.Posachedwapa, National Cardiogenic Shock Management Standardization Campaign inakhazikitsidwa ku United States, ndipo National Cardiogenic Shock Initiative ikufuna kupititsa patsogolo kupulumuka, makamaka kwa odwala. ndi acute coronary syndrome (ACS) .Cholinga chathu chinali kudziwa momwe kugwedezeka kwa cardiogenic kwachiwiri kwa ACS kumafuna thandizo la makina ozungulira kuzungulira kumayendetsedwa mu bungwe lathu ndikufanizira zizindikiro zachipatala pakati pa opulumuka ndi omwe sali opulumuka.
Kafukufuku wobwerera m'mbuyo wa odwala azaka za 18-89 omwe amafunikira chithandizo kwakanthawi kochepa mumayendedwe a ACS ku University of Texas Lubbock Medical Center kuyambira Ogasiti 2018 mpaka Ogasiti 2019. sum test idagwiritsidwa ntchito pamitundu yosiyanasiyana komanso yopitilira.
Odwala okwana 39 anaphatikizidwa, 90% anali amuna, zaka zapakati zinali zaka 62, 62% anali ndi matenda a shuga, ndipo chiwerengero chachikulu cha thupi chinali 29.01 ± 5.84 kg / m2. Pampu ya baluni ya Intra-aortic inali yogwiritsidwa ntchito kwambiri chipangizo chothandizira, chotsatiridwa ndi Impella (92% vs 8%). Chiwopsezo cha imfa chonse chinali 18%.Kuthamanga kwa mtima ndi lactate pa kuvomereza panthawi yogwiritsira ntchito makina kumagwirizanitsidwa ndi imfa (105 bpm vs 83.91 bpm, p = 0.02) (6.85) mmol / l vs 2.55 mmol / lp, 0.003. Percutaneous coronary intervention (PCI) Kukhalapo kwa chithandizo cham'mbuyo cha makina kapena kupatsirana kwa coronary artery bypass grafting (CABG) mu 44% ya odwala kunagwirizanitsidwa ndi kupulumuka (53% vs 0% p = 0.01) .
Kuthamanga kwa mtima kwapamwamba ndi mlingo wa lactate panthawi ya kuikidwa kwa chithandizo cha makina kumayenderana ndi imfa kwa odwala omwe ali ndi matenda a cardiogenic shock secondary to acute coronary syndrome.Kuyambitsa chithandizo chamagetsi pamaso pa PCI kugwirizana ndi kupulumuka.Maphunziro akuluakulu ndi okhwima kwambiri amafunika kuti afotokoze mayanjanowa.
Kusamalira hidradenitis suppurativa (HS) kungakhale kovuta.Nthawi zambiri, zizindikiro za odwala zimakhala bwino pambuyo pochitapo kanthu koyambirira.Mwamwayi, zochitika zina zimakhala zotsutsana ndi kubwereza zodzoladzola ndi zowawa.Opaleshoni nthawi zambiri imagwiritsidwa ntchito kuwononga kapena kuchotsa minofu yomwe imakhudzidwa kuti ichiritse machiritso. .Timafotokoza za wodwala yemwe anali wosagwirizana ndi opaleshoni yemwe adachitidwapo ma radiation a electron beam radiation.
Bambo wina wazaka 44 yemwe anali ndi matako, gluteal cleft, perineum, ndi ntchafu yapakati pa HS. Okwana mlingo wa 30 Gy mu 10 anagawa Mlingo ndipo anakhalabe kuyankha pang'ono kwa 2 milungu chiyambi cha mankhwala. madera.Pa nthawiyo, odwala adanena kuti amachepetsa ululu ndi madzi.Kuyankha kunkaonedwa kuti ndi kolimba pa 6 ndi miyezi 12 pambuyo pa chithandizo.
Thandizo la radiation lili ndi phindu losawerengeka la matenda osiyanasiyana owopsa ndipo laphunziridwa pamlingo wochepa (nthawi zina mlingo umodzi) poyang'anira HS.Tidasankha kugwiritsa ntchito njira yogawanika yomwe timakhulupirira kuti ndiyotetezeka komanso yokhalitsa kwambiri potengera kuchepetsa zotsatira zoyipa.
Malo ochizira odwala omwe akuwonetsa hidradenitis suppurativa m'matako, gluteal cleft, perineum ndi ntchafu zam'mbali zisanachitike chithandizo.
Thandizo lachiphamaso la electron beam radiation therapy ndi lothandiza pochiza matenda owopsa ndipo limakhala ndi lonjezo la HS.Studies of the total dose and fractionation regimens ndi zofunika kuti muwongolere ndi kutsogolera ntchito yamtsogolo.
Pachiŵerengero cha anthu a ku United States, 1 mwa anthu 5,000 ali ndi myopathy ya mitochondrial.Mawonetseredwe azachipatala akhoza kugawidwa pafupifupi m'magulu atatu: ophthalmoplegia yakunja, matenda a skeletal-CNS kapena myopathy. hypertrophic cardiomyopathy, dilated cardiomyopathy, kapena conduction abnormalities.Timapereka vuto la kufooka kwa m'munsi, kupweteka, ndi kutupa ndi matenda a mitsempha ya mitsempha ya mitochondrial myopathy.Kufotokozera mwachidule: Mnyamata wina wazaka 21 yemwe anamaliza maphunziro awo adatumizidwa ku chipatala chathu. pambuyo pa masabata a 3 a kufooka kwa mwendo, kupweteka, ndi kutupa atafika ku United States kuchokera ku India.Kufufuza kunawonetsa tachycardia, 2 + mfundo za pitting edema m'mawondo onse, 4 / 5 MRC-grade kufooka, kufatsa pang'ono m'magulu a minofu ya proximal ndi distal za kumtunda ndi kumunsi kwa malekezero, palibe zozama za tendon, kutsika kwa phazi, ndi ptosis yapakati komanso kuletsa kuyenda kwapadera.Zotsatira zoyambirira za labotale zimasonyeza kuti creatinine kinase yawonjezeka ndi 691 IU / L, ubongo wa natriuretic peptide inawonjezeka ndi 3437 pg / mL, troponin inawonjezeka ndi 47.1 ng/L, myoglobin idakwera ndi 195 ng/mL, ndipo lactate idakwera ndi 7.7 mmol/L, serum bicarbonate idatsika ndi 12 mmol/L. Chifuwa X-ray ndi CT angiography ya pachifuwa / pamimba / chiuno chinawonetsa kukulitsa mtima ndi kuchuluka kwa voliyumu. Bedi lake la ECHO likuwonetsa kumanzere kwa systemic hypokinesia, 40-44% kagawo kakang'ono ka ejection, ndi matenda oopsa a m'mapapo. wodwala anagonekedwa m'chipinda chachipatala cha odwala kwambiri chifukwa cha kutsika kwamphamvu kwambiri.Ophthalmology inatsimikizira ophthalmoplegia, kupatula cranial nerve palsy, myasthenia gravis, ndi retinitis pigmentosa.Gq1b antibody negative.Kuchuluka kwa autoimmune ndi matenda opatsirana sikuthandiza. a wodwalayo rectus femoris minofu anasonyeza anamwazikana buluu ndi cytochrome-c oxidase alibe ulusi ndi kuchuluka perimuscular ndi endomysial connective minofu, mogwirizana ndi yogwira ndi aakulu chachikulu mitochondrial myopathy.Endomyocardial biopsy anasonyeza yogwira lymphocytic myocarditis. Metoprolol ndi methylprednisolone.
Myositis yowonekera ngati myocarditis iyenera kudzutsa kukayikira za matenda a mitochondrial. Zomwe takumana nazo zimatsimikizira kufunika kogwiritsa ntchito gulu losiyanasiyana. njira yodziwira ma pathologies osowa omwe amakhudzidwa kwambiri ndi ma multisystem.
Cholinga cha phunziroli chinali kufufuza mwayi wopeza Gaisbock kwa odwala omwe ali ndi polycythemia ndi matenda oopsa.
Bambo wina wonenepa kwambiri wazaka 40 wa ku Caucasus adagonekedwa m'chipatala ndikutupa kwa mwendo komanso kuchuluka kwa oxygen patatha milungu iwiri atagonekedwa m'chipatala ndi chibayo cha COVID-19. zaka khumi pa maulendo angapo. Mbiri yachipatala yaposachedwapa ikuphatikizapo matenda a deep vein thrombosis (DVT) mu mwendo womwewo miyezi iwiri ndi theka yapitayo, ndi chithandizo ndi Xarelto.
Wodwalayo anafotokoza mbiri ya zaka za 12 za testosterone yotsika. anagwiritsa ntchito CPAP.Wodwalayo amasuta fodya theka la fodya tsiku lililonse kwa zaka 13 zotsatizana, paketi imodzi patsiku, kwa zaka 10 zotsatizana, ndipo anasiya kusuta zaka 12. Anathera nthawi yambiri ya moyo wake akugwira ntchito zolimba m’ntchito yomanga.
Nthawi yotumiza: Jun-29-2022